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Patients with neurofibromatosis 1 (NF1) have a predisposition to cancers, particularly leukemia. We report a 7-year-old girl with NF1 who presented with acute non-lymphoblastic leukemia (ALL). She had no history of leukemia and had no manifestation of NF1. A physical examination was significant for a cafe au lait spot. The initial work-up demonstrated multiple non-adherent leukocytic elements and a non-lymphocytic predominance in the bone marrow. Flow cytometry revealed a population of cells with a FAB-type ALL classification. The patient had no remission after 4 induction courses with high doses of cytosine arabinoside and prednisone, and was dependent on marrow-supplemented red blood cell support and platelet transfusions.Esterified phosphatidylethanolamine plasmalogens and their distribution in brain cell membranes of inbred mouse strains.
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